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Gold nanoparticles to aid in cancer disease management

Amity University Rajasthan, Jaipur develops therapeutic agents from nano-biotechnological approaches

Researchers at Amity University Rajasthan, Jaipur have developed therapeutic agents with the help of nano-biotechnological approaches using a unique solution of ‘gold nanoparticles’ that helps in improving the site-specific drug delivery for cancer disease management and its effective treatment. 

Dr Hemant Kumar Daima, Dr Akhela Umapathi and Prof SL Kothari from the Amity Centre for Nanobiotechnology and Nanomedicine (ACNN), have formulated ‘gold nanoparticles’ solution with a distinctive functional surface containing biomolecules and antibiotics for improved anticancer activity through the selective generation of reactive oxygen species (ROS). The results have revealed that the appropriate surface corona on the gold nanoparticles was essential for effective cancer treatment in a selective manner. 

The research was extended toward lung cancer cells using functional silver nanoparticles and the selective anti-cancer effect originating from the surface chemistry of silver nanoparticles was demonstrated in a paper published in the study published in the journal Colloids and Surfaces A: Physicochemical and Engineering Aspects. Both studies have provided a deeper understanding of the mechanism of anti-cancer actions of functional nanoparticles.

The research was a global effort with researchers from the University of Miyazaki, Japan; and RMIT University, Australia actively participating in it. Now, the team is planning clinical studies on the formulated nanoparticles. 

Some of the important physicochemical characterisation and biological studies of gold nanoparticles were performed on Fourier-transform infrared spectroscopy (FTIR), Fluorescent microscopy facilities acquired through the Fund for Improvement of S&T Infrastructure (FIST) programme of the Department of Science and Technology, Government of India. The study will open new opportunities for better cancer management and treatment, and pave a way for future nanomedicine even beyond cancer. 

PIB

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