The study analysed data from GenomegaDB, the most extensive genetic database of Indians, focusing on individuals aged 85 years and older
MapmyGenome has published its latest research in NPJ Aging (Nature.com). The study, ‘Genetic Variants Associated with Longevity in Long-Living Indians,’ explores the genetic factors contributing to healthy ageing and long life spans in the Indian population.
The study analysed data from GenomegaDB, the most extensive genetic database of Indians, focusing on individuals aged 85 years and older, referred to as Long Living Individuals (LLIs). By comparing LLIs with younger controls (18-49 years), researchers uncovered key genetic variants contributing to ageing longevity, and resistance to various diseases.
Key findings from the study
Genetic Defenses Against Diseases:
Variants linked to slower heart rate (MYH6), reduced risk of osteoporosis and shorter body height (ESR1), and decreased risks of schizophrenia (RIMS1-KCNQ5) and anxiety (HSPA5) were notably more frequent in LLIs.
Conversely, variants associated with increased risk of atrial fibrillation (GORAB-PRRX1) and biliary disorders (ABCC2) were less frequent in this group.
International Connection:
The study confirmed the significance of the FOXO3A gene, a well-known marker for longevity in Japanese, German, and French centenarians, in the Indian population as well.
Pathways Driving Longevity:
The findings highlight the role of genes involved in oxidative stress, DNA repair, apoptosis, glucose metabolism, and energy regulation, all of which play a crucial role in promoting healthy ageing.
“This research represents a monumental step forward in unravelling the genetic code of longevity,” said Anuradha Acharya, Founder and CEO, MapmyGenome. “Our findings not only reveal the genetic underpinnings of long life in Indians but also provide valuable insights into the biological mechanisms that promote healthy ageing.”
By identifying genetic variants unique to Indian LLIs, the study adds a critical dimension to global ageing research. It emphasises the diversity in genetic factors influencing longevity and underscores the importance of population-specific studies in understanding the broader genetic landscape.
Implications for personalised health and ageing
For consumers, this study has profound implications. It highlights the potential of genetic testing in helping individuals understand their predisposition to age-related diseases and develop personalised strategies for healthy ageing.
Proactive Health Management:
Insights into protective and risk-associated genetic variants can empower individuals to take preventive measures against conditions like cardiovascular diseases, osteoporosis, and anxiety.
Tailored Wellness Plans:
Genetic insights enable healthcare professionals to design targeted interventions, including lifestyle changes, dietary recommendations, and therapies, to optimise ageing outcomes.
Global Relevance:
By validating the role of genes like FOXO3A, this research bridges Indian and global longevity studies, highlighting common genetic threads while acknowledging unique regional variations.
“Our mission is to transform lives through genetics,” said Acharya. “This research reinforces our commitment to advancing scientific knowledge and empowering individuals with actionable insights for a healthier future.”
