Amrita Hospital, Faridabad introduces CAR T-cell Therapy for patients with blood cancers

Enters into a strategic partnership with ImmunoACT

Amrita Hospital in Faridabad has introduced CAR T-cell (Chimeric antigen receptor) therapy for certain cancer patients, which is considered a significant breakthrough in B cell lymphoma and leukaemia treatment, with promising results in relapsed and refractory patients. Four patients with B-cell Lymphoma have already undergone or undergoing this therapy at Amrita Hospital so far and they are under follow-up.

Dr Prashant Mehta, Senior Consultant, Program Director (Lymphoid neoplasms & Cellular Therapy), Dept. of Medical Oncology/ Haematoncology/BMT, Amrita Hospital, Faridabad said, “The treatment of cancer has improved immensely in the last few decades, and now we are in an era where we can harness the power of our immunity and channelise its strength to target cancer cells, with minimum effects on other organs or the body as a whole. A novel and refined way of harnessing our immune cells is CAR T-cell therapy which, in the true sense of the word, is composed of ‘living drugs.’ CAR-T cells are living T-lymphocytes of a patient which are genetically reprogrammed to target specific proteins on the surface of cancer cells and kill them. This kind of ‘cellular therapy’ treatment has been proven to be very effective for only some types of blood cancers as of now (B-cell Lymphoma, B-cell ALL & Multiple Myeloma).”

The procedure involves extracting white blood cells from the patient. The T lymphocytes so extracted are modified to express the chimeric antigen receptor (CAR) on their surface. This takes about three to four weeks, after which these cells are infused back into the patient after conditioning chemotherapy. This ‘living drug’ can stay in the patient’s body for many months and years, killing all residual cancer cells and even curing resistant cancers. Unlike chemotherapy, CAR T-cell therapy is generally administered only once to the patient and holds the promise of a permanent cure for certain specific types of cancer.

Dr Mehta said, “At present, CAR T-cell therapy is helpful in relapsed /refractory B cell ALL, more as a bridge to Allogenic BMT, except in patients who are not eligible for intensive treatment where it can be used as a definitive treatment. Similarly, it is useful in relapsed/ refractory B cell lymphoma and Myeloma. This therapy does not work for all patients, and one must discuss with the treating oncologist whether they could be candidates for this treatment. CAR T-cell therapy, in suitable high-grade B cell Lymphoma patients can provide a response rate of 70 per cent and a long-term cure rate of about 40 per cent. In relapsed/refractory B cell ALL (Acute Lymphoblastic Leukemia) response rates are 90 per cent and the long-term cure rate is about 60 per cent for CAR T-cell therapy.”

Said Dr Sanjeev Singh, Medical Director, Amrita Hospital, Faridabad, “Administration of CAR T-cell therapy at Amrita Hospital opens the door to many more patients to avail this treatment, as this therapy has so far been inaccessible to most Indians. We are closely collaborating with researchers in India and abroad in the field of CAR immunotherapy and aim to improve access to CAR immune cell therapies for those in need. We are now developing a national-level collaborative cell therapy lab which will cater to the needs of patients on a larger scale. The goal is to develop ‘Institutional CAR T-cells’ in our hospital which will improve access to this treatment and bring it within reach of most of the Indian population.”

Amrita Hospital, Faridabad and ImmunoACT have entered into a strategic partnership to ensure patients across all segments benefit from this life-saving advanced medicine.

As per ImmunoACT’s Founder and CEO, Dr Rahul Purwar, “Our vision is to ensure that cutting-edge cell and gene therapy products are available in India through indigenous R&D that provides access at affordable price. We need to put India on the global map in the space of advanced medicines.” Adding, ImmunoACT’s Co-founder, and Director – Strategy and Business Development, Shirish Arya said, “NexCAR19’s clinical results are benchmarked with the best-in-class globally in terms of efficacy and outperforms on its safety profile. We are proud to partner with Amrita Hospitals to launch this made-in-India product for the benefit of patients across all sections of society in India”.